Organic letters

An unprecedented approach to 4, 5-disubstituted pyrimidine derivatives by a ZnCl2-catalyzed three-component coupling reaction

T Sasada, F Kobayashi, N Sakai, T Konakahara

文献索引：Sasada, Toshiaki; Kobayashi, Fuminori; Sakai, Norio; Konakahara, Takeo Organic Letters, 2009 , vol. 11, # 10 p. 2161 - 2164

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被引用次数: 71

摘要

We have developed a ZnCl2-catalyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4, 5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono-and disubstituted pyrimidine derivatives, using methyl ketone derivatives instead of enamines.