Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

L Lengyel, TZ Nagy, G Sipos, R Jones, G Dormán…

文献索引：Fujisawa Pharmaceutical Co., Ltd. Patent: US6348474 B1, 2002 ; Location in patent: Page column 65 ;

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被引用次数: 16

摘要

... esters) readily undergo pericyclic annulation reactions at high temperatures if they are located in a ... hydroxyquinoline 10c and analogues 10a,b (Table 1, 10a–c, EW = CN, CO 2 Et ... Yield: 55–65% (Procedure B1), 45% (Procedure B2) (if necessary the compounds were purified by ...