Synthesis of N-Acetoxy-N-benzoyl-2-aminofluorene, an Ultimate Carcinogen by LTA Oxidation of α-Phenyl-N-(2-aminofluorenyl) nitrone, and N-(2′-Deoxyguanosin-8 …
H Mallesha, KRR Kumar, KS Rangappa
文献索引：Mallesha; Ravi Kumar; Rangappa Synthesis, 2001 , # 16 p. 2415 - 2418
Abstract The rearrangement of a new α-phenyl-N-(2-aminofluorenyl) nitrone (8) to a new ultimate carcinogen, N-acetoxy-N-benzoyl-2-aminofluorene (9) is achieved in a lead tetraacetate (LTA) oxidation reaction. Compound 9 reacts with deoxyguanosine (dG) at pH 7.0 to give N-(benzoyl)-N-(deoxyguanosin-8-yl)-2-aminofluorene (10). Subsequent debenzoylation with the heterogeneous system (sodium carbonate/methanol) leads to the ...
