Synthesis of Functionalized Pyrano [3, 2??c] pyridines and Their Transformations to 4??Hydroxy??3 [(1 E)??N??hydroxyalkanimidoyl] pyridones

FA El??Essawy, AF Khattab, MA Zahran…

文献索引：El-Essawy, Farag A.; Khattab, Ahmed F.; Zahran, Magdy A.; Gomaa, Sherif H. Synthetic Communications, 2007 , vol. 37, # 18 p. 3225 - 3237

全文：HTML全文

被引用次数: 2

摘要

Abstract Reaction of 4??hydroxy??6??methyl??2 (1H)??pyridones 1a and 4??hydroxy??1, 6?? dimethyl??2 (1H)??pyridones 1b with diethyl malonates 2a–e leads to the formation of pyrano [3, 2??c] pyridines 4a–j. Degradation of 4a–i affords the corresponding ketones 6a–i. Condensation of ketones 6a–i with hydroxyl amine or phenyl hydrazine hydrochloride is described.