Tetrahedron

New synthetic routes towards various α-fluorinated aryl ketones and their enantioselective reductions using baker's yeast

B Barkakaty, Y Takaguchi, S Tsuboi

文献索引：Barkakaty, Balaka; Takaguchi, Yutaka; Tsuboi, Sadao Tetrahedron, 2007 , vol. 63, # 4 p. 970 - 976

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被引用次数: 15

摘要

Highly electrophilic dichlorofluoromethyl aryl ketones were obtained by oxidation of dichlorofluoromethyl aryl alcohols. Subsequent dechlorination of these ketones using sodium formaldehyde sulfoxylate (Rongalite) and reductive dehalogenating system SnCl2/Al led to various fluoromethyl aryl ketones and chlorofluoromethyl aryl ketones, respectively. Asymmetric reductions of these fluorinated ketones using the inexpensive ...