First Gewald reaction ignited by sodium polysulfide: greener ultrasound-promoted synthesis of substituted 2-aminothiophenes in the absence of catalyst

C Liang, D Lei, X Wang, Q Zhang…

文献索引：Liang, Chengyuan; Lei, Dong; Wang, Xiuzhen; Zhang, Qingqing; Yao, Qizheng Journal of Sulfur Chemistry, 2013 , vol. 34, # 5 p. 458 - 463

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被引用次数: 3

摘要

In this paper, a modified and facile Gewald reaction triggered by sodium polysulfide in the absence of catalytic base was developed. This approach involves a one-pot ultrasound- irritated aqueous reaction between ketones or aldehydes, malononitrile, and sodium polysulfide, which are converted into the corresponding 2-aminothiophene derivatives in moderate to high yields. In comparison with conventional methods, the prominent features ...