N??1 and C??2 substituted tryptophans as potential inhibitors of sickle cell hemoglobin gelation

…, BL Stockwell, P Manavalan, L Kar…

文献索引：Prasitpan; Patel; De Croos; Stockwell; Manavalan; Kar; Johnson; Currie Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 335 - 341

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被引用次数: 10

摘要

Abstract A series of N-1 or C-2 phenylalkyl substituted tryptophans and C-1 phenylalkyl substituted 3, 4-dihydro-β-carbolines were prepared from the apropriate aniline, 1b or 1e, or tryptophan, 8 or 11, by ring closure methods. None of the compounds prepared were more potent than 5-bromotryptophan (11) as inhibitors of sickle cell hemoglobin gelation.