Synthesis, cytotoxicity and in vitro antileishmanial activity of naphthothiazoles

…, V Manfrim, CF Pinzan, AS Araujo…

文献索引：de Toledo, Juliano S.; Junior, Paulo E. S.; Manfrim, Viviane; Pinzan, Camila F.; de Araujo, Alexandre S.; Cruz, Angela K.; Emery, Flavio S. Chemical Biology and Drug Design, 2013 , vol. 81, # 6 p. 749 - 756

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被引用次数: 4

摘要

The leishmaniasis is a spectral disease caused by the protozoan Leishmania spp., which threatens millions of people worldwide. Current treatments exhibit high toxicity, and there is no vaccine available. The need for new lead compounds with leishmanicidal activity is urgent. Considering that many lead leishmanicidal compounds contain a quinoidal scaffold and the thiazole heterocyclic ring is found in a number of antimicrobial drugs, we ...