Design, synthesis, and biological evaluation of thio-containing compounds with serum HDL-cholesterol-elevating properties

…, M Abou-Gharbia, JA Butera, SY Chai…

文献索引：Elokdah, Hassan; Sulkowski, Theodore S.; Abou-Gharbia, Magid; Butera, John A.; Chai, Sie-Yearl; McFarlane, Geraldine R.; McKean, Mar-Lee; Babiak, John L.; Adelman, Steven J.; Quinet, Elaine M. Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 681 - 695

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被引用次数: 56

摘要

A novel series of substituted sulfanyldihydroimidazolones (1) that modulates high-density lipoprotein cholesterol (HDL-C) has been reported to have HDL-elevating properties in several animal models. Concerns about the chemical and metabolic stability of 1 directed us to explore the structure-activity relationship (SAR) of a related series of substituted thiohydantoins (2). Expansion of the scope of the thiohydantoin series led to exploration of ...