2-(Alkylthio)-1, 2, 4-triazolo [1, 5-a] pyrimidines as adenosine 3', 5'-monophosphate phosphodiesterase inhibitors with potential as new cardiovascular agents

T Novinson, R Springer, DE O'Brien…

文献索引：Novinson; Springer; O'Brien; Scholten; Miller; Robins Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 420 - 426

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被引用次数: 44

摘要

The condensation of 3-amino-5-(benzylthio)-s-triazole (lla) 19 or 3-mino-5-[(p-chlorobenzyl) thio]-s-triazole (llb) with acetylacetone gave 2-(benzylthio)-5, 7-dimethyl-s-triazolo [1, Balpyrimidine (12a) and 2-[(p-chlorobenzy1)-thio]-5, 7-dimethyl-s-triazolo [1, 5-a] pyrimidine (1 2b), respectively. The structure of 12a was established as follows. According to the general procedure of Williams, 2o we have condensed 3-amino-5-thio-s-triazole (8) with ...