Archiv der Pharmazie

A Novel Antifungal Agent with Broad Spectrum: 1??(4??Biphenylyl)??3??(1H??imidazol??1??yl)??1??propanone

G Roman, M Mareş, V Năstasă

文献索引：Roman, Gheorghe; Mares, Mihai; Nastasa, Valentin Archiv der Pharmazie, 2013 , vol. 346, # 2 p. 110 - 118

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被引用次数: 9

摘要

Abstract A series of (1-substituted aryl)-3-(1H-imidazol-1-yl)-1-propanones was synthesized through the N-alkylation of imidazole with 3-dimethylamino-1-(substituted aryl)-1-propanone hydrochlorides (ketonic Mannich bases). A second series of N 1-substituted imidazoles was obtained by the reduction of the carbonyl function of the imidazole–ketones in the previous series by means of NaBH 4. All of the compounds were evaluated for antifungal activity ...