Anticoccidial derivatives of 6-azauracil. 5. Potentiation by benzophenone side chains

…, BL Mylari, LR Chappel, HL Howes Jr…

文献索引：Carroll; Miller; Mylari; Chappel; Howes Jr.; Lynch; Gupta; Rash; Koch Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 96 - 100

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被引用次数: 17

摘要

Attachment of p-benzophenone side chains at N1 was found to be one of the moat effective modifications for enhancing the potency of 6-azauracil against a broad spectrum of coccidia in chickens. Compound 20 was about 1000-fold more potent than &azauracil. Structure- activity relationships paralleled those found in a previously reported series of related analoguea containing diphenyl sulfide and sulfone side chains. Drug metabolism studies ...