Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential …
MA Avery, M Alvim-Gaston, JA Vroman…
文献索引：Avery, Mitchell A.; Alvim-Gaston, Maria; Vroman, Jeffrey A.; Wu, Baogen; Ager, Arba; Peters, Wallace; Robinson, Brian L.; Charman, William Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4321 - 4335
On the basis of earlier reported quantitative structure-activity relationship studies, a series of 9β-16-(arylalkyl)-10-deoxoartemisinins were proposed for synthesis. Several of the new compounds 7 and 10-14 were synthesized employing the key synthetic intermediate 23. In a second approach, the natural product (+)-artemisinic acid was utilized as an acceptor for conjugate addition, and the resultant homologated acids were subjected to singlet ...
