Benzothiazoles with a nitrogen substituent in the 2-position have frequently been used as core structures for the development of pharmaceutically important agents. Recent successful examples include the anti-HIV agent 1,[1] the antibacterial compound 2,[2] the PPAR agonist 3,[3] the H3-receptor ligand 4,[4] the nicotinic-acetylcholine-receptor ligand 5,[5] and the phosphodiesterase 10 inhibitor 6 (Scheme 1).[6] Normally, 2-N-substituted benzothiazoles ...
