Organic letters

Transition-Metal-Free Sonogashira-Type Cross-Coupling of Alkynes with Fluoroarenes

G Jin, X Zhang, S Cao

文献索引：Jin, Guanyi; Zhang, Xuxue; Cao, Song Organic Letters, 2013 , vol. 15, # 12 p. 3114 - 3117

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被引用次数: 22

摘要

A novel, inexpensive, and efficient palladium-, copper-, ligand-, and amine-free Sonogashira- type cross-coupling reaction of terminal alkynes with unreactive aryl fluorides in the presence of sodium, sodium methoxide, and calcium hydroxide under the assistance of a Grignard reagent was developed. A plausible mechanism was also suggested.