Synthesis

Hofmann-type elimination in the efficient N-alkylation of azoles: imidazole and benzimidazole

A Horvath

文献索引：Horvath Synthesis, 1994 , # 1 p. 102 - 106

全文：HTML全文

被引用次数: 19

摘要

A simple and eflicient preparation of 1-substituted 1H-azoles (imidazole and benzimidazole) has been developed, which involves a selective Hofmann-type elimination of the 2- cyanoethyl group from the azolium salts obtained by the reaction of halides with lH- imidazole-1-propanenitrile and 1H-benzimidazole-1-propanenitrile. Overall yields of 1- substituted lH-azoles decreased in the order: primary alkyl halides 2 allylhalides 2 ...