Synthesis of some novel benzofuran-2-yl (4, 5-dihyro-3, 5-substituted diphenylpyrazol-1-yl) methanones and studies on the antiproliferative effects and reversal of …

…, A Radadiya, N Pandya, J Serly, J Molnár…

文献索引：Parekh, Shrey; Bhavsar, Dhairya; Savant, Mahesh; Thakrar, Shailesh; Bavishi, Abhay; Parmar, Manisha; Vala, Hardevsinh; Radadiya, Ashish; Pandya, Nilay; Serly, Juliana; Molnar, Joseph; Shah, Anamik European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1942 - 1948

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被引用次数: 35

摘要

A new series of benzofuran-2-yl (4, 5-diydro-3, 5-substituted diphenylpyrazol-1-yl) methanone derivatives 8a–x by the reaction of the benzofuran-2-carbohydrazides 7 with various chalcone derivatives 3a–x using microwave irradiation has been described. The effect of synthesized compounds 8a–v was studied against human cancer cell lines for their antiproliferative activity and reversal of multidrug resistance on human MDR1-gene ...