Effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes

DE Nichols, DH Lloyd, AJ Hoffman…

文献索引：Nichols, David E.; Lloyd, David H.; Hoffman, Andrew J.; Nichols, Maxine B.; Yim, George K. W. Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 530 - 535

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被引用次数: 190

摘要

The enantiomers of 3, 4-(methy1enedioxy) amphetamine (MDA), p-methoxyamphetamine (PMA), and N-Me-MDA (MDMA), along with their a, a-dimethylated derivatives, were evaluated for an effect on the release of [3H] serotonin from rat whole brain synaptosomes. The amphetamine isomers were all potent in inducing the release of [3H] serotonin at bath concentrations of 1 and 10 yM but were inactive at 0.1 yM. No significant difference in ...