Tetrahedron Letters

Highly efficient dialkylphosphate-mediated syntheses of hydantoins and a bicyclohydantoin under solvent-free conditions

V Kumar, H Rana, R Sankolli, MP Kaushik

文献索引：Kumar, Vinod; Rana, Hemlata; Sankolli, Ravish; Kaushik Tetrahedron Letters, 2011 , vol. 52, # 46 p. 6148 - 6151

全文：HTML全文

被引用次数: 11

摘要

Diversely substituted hydantoins have been synthesized by new strategy from cyanamide based precursor, that is, methyl N-cyano-N-alkyl/arylaminoacetate. Dialkylphosphates were employed as the mild reagent to hydrolyze and cyclize the substrate in one step to give quantitative yields of the desired products. Syntheses of multivalent hydantoins viz bis- hydantoin, bicyclohydantoin have potentially widened the scope and applicability of the ...