1-substituted-1, 2, 5, 6-tetrahydropyridine-3-carboxaldehyde-O-alkyloximes as novel orally active and long-lasting muscarinic cholinergic agonists

E Toja, C Bonetti, A Butti, P Hunt, M Fortin…

文献索引：Toja, E; Bonetti, C; Butti, A; Hunt, P; Fortin, M; et al. European Journal of Medicinal Chemistry, 1992 , vol. 27, # 5 p. 519 - 526

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被引用次数: 11

摘要

Abstract Our previous attempts to design muscarinic agonists related to arecoline with the prerequisites for clinical use were successful with the discovery of 1, 2, 5, 6- tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride, RU 35963, and structurally related compounds, in which the metabolically labile ester group of arecoline was replaced with the bioisosteric and stable aldoxime group. With the aim of obtaining ...