Tetrahedron letters

A new simple and quantitative synthesis of α-aminoacid-N-carboxyanhydrides (oxazolidines-2, 5-dione)

H Collet, C Bied, L Mion, J Taillades, A Commeyras

文献索引：Collet, Helene; Bied, Catherine; Mion, Louis; Taillades, Jacques; Commeyras, Auguste Tetrahedron Letters, 1996 , vol. 37, # 50 p. 9043 - 9046

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被引用次数: 62

摘要

Nitrosation of chiral N-carbamoylaminoacids with a mixture of NO and O2 gives, with the same configuration and in quantitative yield the corresponding α-aminoacid-N- carboxyanhydrides (NCA), well known precursors of peptides. The by products of this reaction are N2 and H2O.