Discovery of non-Zwitterionic GABA A receptor full agonists and a superagonist

…, ESH Chow, RL Barlow, JR Bloomquist

文献索引：Carlier, Paul R; Chow, Ella S-H; Barlow, Rebecca L; Bloomquist, Jeffrey R Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 15 p. 1985 - 1988

全文：HTML全文

被引用次数: 15

摘要

Numerous previous studies of GABAA receptor ligands have suggested that GABAA receptor agonists must be zwitterionic and feature an intercharge separation similar to that of GABA (approx. 4.7–6Å). In this communication we demonstrate that appropriately functionalized GABA amides are partial, full, or superagonists, despite their non-zwitterionic structure.