N-substituted hydroxyureas as urease inhibitors.

S Uesato, Y Hashimoto, M Nishino, Y Nagaoka…

文献索引：Uesato, Shinichi; Hashimoto, Yuichiro; Nishino, Masaru; Nagaoka, Yasuo; Kuwajima, Hiroshi Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 9 p. 1280 - 1282

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被引用次数: 31

摘要

In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl-or phenyl- substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl-(10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.