Synthesis and evaluation of novel 4-nitropyrrole-based 1, 3, 4-oxadiazole derivatives as antimicrobial and anti-tubercular agents

…, P Bangalore, SD Borhade, PK Khandare

文献索引：Rane, Rajesh A.; Bangalore, Pavankumar; Borhade, Sheetal D.; Khandare, Preeti K. European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 49 - 58

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被引用次数: 37

摘要

Abstract We report synthesis and antimicrobial evaluation of 42 novel 4-nitropyrrole-based 1, 3, 4-oxadiazoles. The synthesized molecules were evaluated for anti-bacterial, anti-fungal and anti-tubercular activities. Promisingly, most of the compounds showed equal or more potency than standard ciprofloxacin against Staphylococcus aureus, Bacillus subtilis and Escherichia coli. Compound 5e exhibited highest anti-tubercular activity (0.46 μg/mL) ...