Alteration of the substrate specificity of the angular dioxygenase carbazole 1, 9a-dioxygenase

…, T Horisaki, T Umeda, H Noguchi, Y Usami…

文献索引：Uchimura, Hiromasa; Horisaki, Tadafumi; Umeda, Takashi; Noguchi, Haruko; Usami, Yusuke; Li, Li; Terada, Tohru; Nakamura, Shugo; Shimizu, Kentaro; Takemura, Tetsuo; Habe, Hiroshi; Furihata, Kazuo; Omori, Toshio; Yamane, Hisakazu; Nojiri, Hideaki Bioscience, Biotechnology and Biochemistry, 2008 , vol. 72, # 12 p. 3237 - 3248

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被引用次数: 8

摘要

Carbazole 1, 9a-dioxygenase (CARDO) consists of terminal oxygenase (CARDO-O) and electron transport components. CARDO can catalyze specific oxygenation for various substrates: angular dioxygenation for carbazole and dibenzo-p-dioxin, lateral dioxygenation for anthracene, and monooxygenation for methylene carbon of fluorene and sulfide sulfur of dibenzothiophene. To elucidate the molecular mechanism determining its unique ...