Design and synthesis of selective inhibitors of placental alkaline phosphatase

…, E Sergienko, AM Simão, Y Su, T Chung…

文献索引：Lanier, Marion; Sergienko, Eduard; Simao, Ana Maria; Su, Ying; Chung, Thomas; Millan, Jose Luis; Cashman, John R. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 573 - 579

全文：HTML全文

被引用次数: 22

摘要

Placental Alkaline Phosphatase (PLAP) is a tissue-restricted isozyme of the Alkaline Phosphatase (AP) superfamily. PLAP is an oncodevelopmental enzyme expressed during pregnancy and in a variety of human cancers, but its biological function remains unknown. We report here a series of catechol compounds with great affinity for the PLAP isozyme and significant selectivity over other members of the AP superfamily. These selective PLAP ...