Aryl sulfonamido indane inhibitors of the Kv1. 5 ion channel

MF Gross, S Beaudoin, G McNaughton-Smith…

文献索引：Gross, Michael F.; Beaudoin, Serge; McNaughton-Smith, Grant; Amato, George S.; Castle, Neil A.; Huang, Christine; Zou, Anruo; Yu, Weifeng Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2849 - 2853

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被引用次数: 39

摘要

A collection of aryl sulfonamido indanes based on the lead compound 1 was synthesized and evaluated for Kv1. 5 inhibitory activity. Kv1. 5 inhibitors have the potential to be atrium- selective agents for treatment of atrial fibrillation.(1R, 2R)-1 has an IC50 of 0.033 μM against Kv1. 5 and is selective against other cardiac ion channels, including hERG.