Tetrahedron: Asymmetry

The first simple and efficient synthesis of the unusual dipeptide part of Phomopsin A

S Chandrasekhar, G Chandrashekar

文献索引：Chandrasekhar, Srivari; Chandrashekar, Gudise Tetrahedron Asymmetry, 2005 , vol. 16, # 13 p. 2209 - 2214

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被引用次数: 13

摘要

The synthesis of unnatural amino acids especially those that are part structures of bioactive molecules, continues to attract the attention of synthetic organic chemists. Phomopsin A 1 1 is one such 13-membered macrocycle with six amino acid residues, which shows cytotoxic activity by interfering with microtubule function through binding to tubulin. This natural product is the main cytotoxin isolated from cultures of Phomospsis leptostromiformis. Biological studies ...