The synthesis of new series of spiropiperidines is reported. Some of these compounds showed interesting adrenergic activity. The biological activities of the new compounds were evaluated on-guinea pig atria (β1), guinea-pig trachea (β2) and rat vas deferens (α). Compounds 6a, 6c and 6f showed activity comparable to propranolol, in spite of being tertiary amines.
![1-(spiro[1,3-benzodioxole-2,4'-piperidine]-1-yl)ethan-1one结构式](https://image.chemsrc.com/caspic/499/185316-84-1.png)
![spiro[benzo[d][1,3]dioxole-2,4'-piperidine]结构式](https://image.chemsrc.com/caspic/003/7677-96-5.png)
