A convenient method for the preparation of chiral phosphonoacetamides and their Horner–Wadsworth–Emmons reaction

…, M Fernández-Zertuche, O García-Barradas

文献索引：Ordonez, Mario; Hernandez-Fernandez, Eugenio; Montiel-Perez, Martin; Bautista, Rafael; Bustos, Paola; Rojas-Cabrera, Haydee; Fernandez-Zertuche, Mario; Garcia-Barradas, Oscar Tetrahedron Asymmetry, 2007 , vol. 18, # 20 p. 2427 - 2436

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被引用次数: 18

摘要

Chiral phosphonoacetamides bearing (S)-(α-methylbenzyl) benzylamine,(S, S)-bis (α- methylbenzyl) amine, l-phenylglycine methyl ester and l-phenylglycinol were easily prepared in good yield by means of the Michaelis–Arbuzov reaction of chiral bromoacetamides obtained in quantitative yield, with trimethyl phosphite, which under Horner–Wadsworth–Emmons conditions with several aryl and alkyl aldehydes under ...