Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A

F Mu, E Hamel, DJ Lee, DE Pryor…

文献索引：Mu, Fanrong; Hamel, Ernest; Lee, Debbie J.; Pryor, Donald E.; Cushman, Mark Journal of Medicinal Chemistry, 2003 , vol. 46, # 9 p. 1670 - 1682

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被引用次数: 47

摘要

Compounds in the lavendustin A series have been shown to inhibit both protein-tyrosine kinases (PTKs) and tubulin polymerization. Since certain lavendustin A derivatives can exist in conformations that resemble both the trans-stilbene structure of the PTK inhibitor piceatannol and the cis-stilbene structure of the tubulin polymerization inhibitor combretastatin A-4, the possibility exists that the ratio of the two types of activities of the ...