Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity

…, MC Wani, SM Natschke, AW Nicholas

文献索引：Wall; Wani; Natschke; Nicholas Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1553 - 1555

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被引用次数: 76

摘要

The antitumor alkaloid 1l-hydroxy-(20S)-camptothecin (4) was isolated from the woody tissue of Camptotheca acuminata. Structural proof derived from comparison with racemic 4 prepared by total synthesis. Antitumor activity of racemic 4 in L1210 leukemia in mice was considerably greater than that of natural (2OS)-camptothecin (1) and its sodium salt. There was also no toxic effect observed even at relatively high doses.