Fluorous derivatives of (1R, 2R)-diaminocyclohexane as chiral ligands for metal-catalyzed asymmetric reactions

J Bayardon, D Sinou, O Holczknecht, L Mercs…

文献索引：Bayardon, Jerome; Sinou, Denis; Holczknecht, Orsolya; Mercs, Laszlo; Pozzi, Gianluca Tetrahedron Asymmetry, 2005 , vol. 16, # 13 p. 2319 - 2327

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被引用次数: 25

摘要

Perfluoroalkyl-substituted, enantiopure diamines derived from (1R, 2R)-diaminocyclohexane were conveniently prepared from readily available precursors. In situ generated metal complexes of these ligands were tested as chiral catalysts in three standard asymmetric reactions (cyclopropanation of styrene, hydrogen transfer reduction of acetophenone, and allylic alkylation of 1, 3-diphenyl-2-propenyl acetate) affording enantioselectivities of up to ...