Structure–Activity Relationships of Targeted RuII (η6-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands

A Kurzwernhart, W Kandioller, S Bächler…

文献索引：Kurzwernhart, Andrea; Kandioller, Wolfgang; Bartel, Caroline; Baechler, Simone; Trondl, Robert; Muehlgassner, Gerhard; Jakupec, Michael A.; Arion, Vladimir B.; Marko, Doris; Keppler, Bernhard K.; Hartinger, Christian G. Chemical Communications, 2012 , vol. 48, # 40 p. 4839 - 4841

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被引用次数: 51

摘要

RuII (arene) complexes have been shown to be promising anticancer agents, capable of overcoming major drawbacks of currently used chemotherapeutics. We have synthesized RuII (η6-arene) compounds carrying bioactive flavonol ligands with the aim to obtain multitargeted anticancer agents. To validate this concept, studies on the mode of action of the complexes were conducted which indicated that they form covalent bonds to DNA, ...