Structure− activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase

…, RH Rais, ON Al Safarjalani, FNM Naguib…

文献索引：Young, Ah Kim; Sharon, Ashoke; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Naguib, Fardos N. M.; El Kouni, Mahmoud H. Journal of Medicinal Chemistry, 2008 , vol. 51, # 13 p. 3934 - 3945

全文：HTML全文

被引用次数: 25

摘要

Several 7-deaza-6-benzylthioinosine analogues with varied substituents on aromatic ring were synthesized and evaluated against Toxoplasma gondii adenosine kinase (EC. 2.7. 1.20). Structure− activity relationships indicated that the nitrogen atom at the 7-position does not appear to be a critical structural requirement. Molecular modeling reveals that the 7- deazapurine motif provided flexibility to the 6-benzylthio group as a result of the absence ...