Synthesis and antibronchospastic activity of 8-alkoxy-and 8-(alkylamino) imidazo [1, 2-a] pyrazines

…, F Laurent, C Sablayrolles, E Rechencq…

文献索引：Bonnet, Pierre A.; Michel, Alain; Laurent, Florence; Sablayrolles, Claire; Rechencq, Eliane; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3353 - 3358

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被引用次数: 60

摘要

Theophylline still occupies a dominant place in asthma therapy. Unfortunatly ita adverse central nervous system (CNS) stimulant effects can dramatically limit ita use, and adjustments in the dosage are often needed. We have synthesized a new series of imidazo [l, aa] pyrazine derivatives which are much more potent bronchodilators than theophylline in vivo and do not exhibit the CNS stimulatory profile. In vitro studies on isolated rat uterus ...