New functionalized Horner-Wadsworth-Emmons reagents: useful building blocks in the synthesis of polyunsaturated aldehydes. A short synthesis of (.+-.)-(E, E)- …
…, T Rein, B Aakermark, P Helquist
文献索引：Kann, Nina; Rein, Tobias; Akermark, Bjoern; Helquist, Paul Journal of Organic Chemistry, 1990 , vol. 55, # 19 p. 5312 - 5323
The new Homer-Wadsworth-Emmons reagents 4 and 5 transform carbonyl compounds into 2, 4-pentadienals and 3-methyl-2, 4-pentadienals, respectively. Reagent 4 gives good yields of the desired products with a variety of aldehydes and ketones; reagent 5 generally gives good yields with aldehydes, but gives lower yields with ketones. The reactions proceed under mild conditions and give the products as predominantly W, 4E isomers, with ...
