Tetrahedron

A straightforward copper-free palladium methodology for the selective alkynylation of a wide variety of S-, O-, and N-based mono-and diheterocyclic bromides and …

S Saleh, M Picquet, P Meunier, JC Hierso

文献索引：Saleh, Samer; Picquet, Michel; Meunier, Philippe; Hierso, Jean-Cyrille Tetrahedron, 2009 , vol. 65, # 34 p. 7146 - 7150

全文：HTML全文

被引用次数: 21

摘要

High-yield alkynylations are successfully achieved by a simple and widely accessible catalytic system for an unprecedented variety of heterocyclic bromides and chlorides in position-2,-3 or-5: pyridine, quinoline, thiophene, furan, thiazole, benzothiazole, pyrimidine, pyridazine, pyrazine, dioxepin halides are efficiently functionalized in short time reactions. This copper-free methodology employs 1mol% palladium only, with inexpensive PPh3 ...