Journal of Peptide Science

COMU: A third generation of uronium??type coupling reagents

A El??Faham, F Albericio

文献索引：El-Faham, Ayman; Albericio, Fernando Journal of Peptide Science, 2010 , vol. 16, # 1 p. 6 - 9

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被引用次数: 48

摘要

Abstract COMU is a third generation of uronium-type coupling reagent based on ethyl 2- cyano-2-(hydroxyimino) acetate (Oxyma) as well as a morpholino carbon skeleton. The presence of the morpholino group has a marked influence on the solubility, stability and reactivity of the reagent. COMU performed extremely well in the presence of only 1 equiv. of base, thereby confirming the effect of the hydrogen bond acceptor in the reaction. The by- ...