Organic letters

Room-Temperature Alternative to the Arbuzov Reaction: The Reductive Deoxygenation of Acyl Phosphonates

SMA Kedrowski, DA Dougherty

文献索引：Kedrowski, Sean M. A.; Dougherty, Dennis A. Organic Letters, 2010 , vol. 12, # 18 p. 3990 - 3993

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被引用次数: 16

摘要

The reductive deoxygenation of acyl phosphonates using a Wolff− Kishner-like sequence is described. This transformation allows direct access to alkyl phosphonates from acyl phosphonates at room temperature. The method can be combined with acyl phosphonate synthesis into a one pot, four-step procedure for the conversion of carboxylic acids into alkyl phosphonates. The methodology works well for a variety of aliphatic acids and shows a ...