The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist

…, D Montanari, M Caivano, P Shah, D Standing…

文献索引：Rimland, Joseph; Dunne, Angela; Hunjan, Suchete S.; Sasse, Rosemary; Uings, Iain; Montanari, Dino; Caivano, Matilde; Shah, Poonam; Standing, David; Gray, David; Brown, David; Cairns, William; Trump, Ryan; Smith, Paul W.; Bertheleme, Nicolas; D'Alessandro, Pier; Gul, Sheraz; Vimal, Mythily; Smith, David N.; Watson, Stephen P. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2340 - 2343

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被引用次数: 6

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The identification of novel, potent, non-steroidal/small molecule functional GR antagonist GSK1564023A selective over PR is described. Associated structure–activity relationships and the process of optimisation of an initial HTS hit are also described. ... The identification of novel, potent, non-steroidal/ ...