Synthesis and anthelmintic activity of 3'-benzoylurea derivatives of 6-phenyl-2, 3, 5, 6-tetrahydroimidazo [2, 1-b] thiazole

…, EB Fraser-Smith, DG Loughhead…

文献索引：Weikert; Bingham Jr.; Emanuel; Fraser-Smith; Loughhead; Nelson; Poulton Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1630 - 1633

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被引用次数: 29

摘要

Reaction of 3-amino derivatives of the nematocides tetramisole and levamisole with variously substituted benzoylisocyanates gave a series of benzoylureas I which were tested for activity against helminths and ectoparasites. Compounds bearing 2, 6-difluoro and 4- trifluoromethyl substituents had potent nematocidal activity in both mice and sheep. No antiectoparasitic activity was observed.