NO donors. Part 18: Bioactive metabolites of GTN and PETN—Synthesis and vasorelaxant properties

…, A Koenig, C Roegler, A Seeling, J Lehmann

文献索引：Lange, Kathrin; Koenig, Andreas; Roegler, Carolin; Seeling, Andreas; Lehmann, Jochen Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3141 - 3144

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被引用次数: 11

摘要

The vasodilators glyceryl trinitrate (GTN) and pentaerythrityl tetranitrate (PETN) are supposed to be degraded in vivo to the lower nitrates PETriN, PEDN, PEMN, 1, 2-GDN, 1, 3- GDN, 1-GMN, and 2-GMN. We synthesized these bioactive metabolites as reference compounds for pharmacokinetic studies. The use of HPLC-methods for monitoring the stepwise reduction of PETN to lower nitrates and the syntheses of the glyceryl dinitrates ...