Platinum (II) complexes with the diethyl aminomethylphosphonate ligand (amp): characterization, properties, and unusual solution behavior

D Cornacchia, L Cerasino, C Pacifico…

文献索引：Cornacchia, Daniele; Cerasino, Leonardo; Pacifico, Concetta; Natile, Giovanni European Journal of Inorganic Chemistry, 2008 , # 11 p. 1822 - 1829

全文：HTML全文

被引用次数: 5

摘要

Abstract Cisplatin is one of the most widely prescribed drugs for the treatment of solid tumors, even though its pharmacological potential is often limited by side effects (nephrotoxicity, neurotoxicity, alopecia) and a limited spectrum of activity. Overcoming these limitations is one of the most chased goals by researchers in the field of medicinal chemistry. Since phosphonates have a great selectivity for bone tissues, we have extended a ...