Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: Synthesis of artificial substrate, homology modelling and initial screening

…, M Anderluh, J Stojan, TL Rižner, S Gobec

文献索引：Brunskole, Mojca; Stefane, Bogdan; Zorko, Karmen; Anderluh, Marko; Stojan, Jure; Lanisnik Rizner, Tea; Gobec, Stanislav Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5881 - 5889

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被引用次数: 9

摘要

Trihydroxynaphthalene reductase (3HNR) is an essential enzyme in the biosynthesis of fungal melanin and it represents an emerging target for the development of new fungicides and antimicotics. To promote the discovery of new inhibitors, an improved chemical synthesis of the artificial substrate 2, 3-dihydro-2, 5-dihydroxy-4H-benzopyran-4-one (DDBO) was developed. A series of compounds were screened on 3HNR from Curvularia ...