Pyrido [2, 3-d] pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4

SN VanderWel, PJ Harvey, DJ McNamara…

文献索引：VanderWel, Scott N.; Harvey, Patricia J.; McNamara, Dennis J.; Repine, Joseph T.; Keller, Paul R.; Quin III, John; Booth, R. John; Elliott, William L.; Dobrusin, Ellen M.; Fry, David W.; Toogood, Peter L. Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2371 - 2387

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被引用次数: 98

摘要

Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide an effective method for the treatment of proliferative diseases such as cancer. The pyrido [2, 3-d] pyrimidin-7-one template has been identified previously as a privileged structure for the inhibition of ATP-dependent kinases, and good potency against Cdks has been reported for representative examples. Obtaining selectivity for individual Cdk enzymes, particularly ...