Second-generation process research towards eletriptan: a fischer indole approach

…, P Hellier, A Pettman, S Watkinson

文献索引：Ashcroft, Christopher P.; Pettman, Alan; Watkinson, Simon; Hellier, Paul Organic Process Research and Development, 2011 , vol. 15, # 1 p. 98 - 103

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被引用次数: 21

摘要

During the assessment of alternative routes to eletriptan, the Fischer indole synthesis was highlighted as a particularly attractive way to build up the molecule. It had the potential to deliver a convergent, highly efficient synthesis (scheme 2), as well as being a well understood and reliable transformation. The Fischer indole reaction was discovered in 1883 by Hermann Emil Fischer,(2) and despite its age, is still one of the most commonly used methods to ...