Tetrahedron

Grignard reagent-promoted 6-endo-dig cyclization: instantaneous synthesis of original dipyrido [1, 2-a: 3′, 4′-d] imidazole

…, M Abarbri, A Gueiffier, C Enguehard-Gueiffier

文献索引：Oudot, Romain; Costes, Philippe; Allouchi, Hassan; Pouvreau, Melanie; Abarbri, Mohamed; Gueiffier, Alain; Enguehard-Gueiffier, Cecile Tetrahedron, 2011 , vol. 67, # 49 p. 9576 - 9581

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被引用次数: 7

摘要

Dipyrido [1, 2-a: 3′, 4′-d] imidazole derivatives can be readily synthetized from various 3- alkyne-2-cyanoimidazo [1, 2-a] pyridines via an efficient Grignard reagent-promoted 6-endo- dig cyclization of nitrile to alkynes. A previous optimization of the Sonogashira coupling reaction at C (3) of the 2-cyanoimidazo [1, 2-a] pyridine was necessary as this coupling reaction is known to be largely influenced by the nature of the 2-substituent.