Tridentate N??Donor Palladium (II) Complexes as Efficient Coordinating Quadruplex DNA Binders

…, JL Mergny, MP Teulade??Fichou

文献索引：Largy, Eric; Hamon, Florian; Rosu, Frederic; Gabelica, Valerie; De Pauw, Edwin; Guedin, Aurore; Mergny, Jean-Louis; Teulade-Fichou, Marie-Paule Chemistry - A European Journal, 2011 , vol. 17, # 47 p. 13274 - 13283

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被引用次数: 33

摘要

Abstract Fifteen complexes of palladium, platinum, and copper, featuring five different N- donor tridentate (terpyridine-like) ligands, were prepared with the aim of testing their G- quadruplex–DNA binding properties. The fluorescence resonance energy transfer melting assay indicated a striking positive effect of palladium on G-quadruplex DNA stabilization compared with platinum and copper, as well as an influence of the structure of the organic ...