The Synthesis and Chemistry of 8??Substituted Bicyclo [5.1. 0] oct??1 (8)??ene

GA Lee, CPK Chen, MY Chen

文献索引：Lee, Gon-Ann; Chen, Calvin Ping-Kuang; Chen, Mei-Yun Journal of the Chinese Chemical Society, 1998 , vol. 45, # 3 p. 381 - 385

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被引用次数: 2

摘要

Abstract 8-Bromobicyclo [5.1. 0] oct-1 (8)-cne (7), an intermediate for the preparation of 8- substituted bicyclo [5.1. 0] oct-1 (8)-enes, was synthesized by denomination of 1, 8, 8- tribromobicyclo [5.1. 0] octane (6). Compound 7 underwent bromo-lithium exchange followed by nucleophilic substitution reactions to generate bicyclo [5.1. 0] oct-1 (8)-ene (5), 8- methylbicyclo [5.1. 0] oct-1 (8)-ene (10), and 8-trimethylsilylbicyclo [5.1. 0] oct-1 (8)-ene ( ...